[1558] | 1 | package de.ugoe.cs.autoquest.tasktrees.alignment.algorithms; |
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| 2 | |
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| 3 | import java.util.ArrayList; |
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| 4 | import java.util.List; |
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| 5 | |
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| 6 | import de.ugoe.cs.autoquest.tasktrees.alignment.substitution.SubstitutionMatrix; |
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| 7 | |
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| 8 | public class SmithWatermanRepeated implements Alignment { |
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| 9 | |
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| 10 | /** |
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| 11 | * The first input |
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| 12 | */ |
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| 13 | private int[] input1; |
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| 14 | |
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| 15 | /** |
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| 16 | * The second input String |
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| 17 | */ |
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| 18 | private int[] input2; |
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| 19 | |
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| 20 | /** |
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| 21 | * The lengths of the input |
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| 22 | */ |
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| 23 | private int length1, length2; |
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| 24 | |
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| 25 | /** |
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| 26 | * The score matrix. The true scores should be divided by the normalization |
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| 27 | * factor. |
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| 28 | */ |
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| 29 | private MatrixEntry[][] matrix; |
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| 30 | |
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| 31 | |
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| 32 | |
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| 33 | private float scoreThreshold; |
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| 34 | |
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| 35 | /** |
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| 36 | * Substitution matrix to calculate scores |
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| 37 | */ |
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| 38 | private SubstitutionMatrix submat; |
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| 39 | |
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| 40 | public SmithWatermanRepeated(int[] input1, int[] input2, SubstitutionMatrix submat,float threshold) { |
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| 41 | this.input1 = input1; |
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| 42 | this.input2 = input2; |
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| 43 | length1 = input1.length; |
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| 44 | length2 = input2.length; |
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| 45 | this.submat = submat; |
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| 46 | |
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| 47 | //System.out.println("Starting SmithWaterman algorithm with a " |
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| 48 | // + submat.getClass() + " Substitution Matrix: " + submat.getClass().getCanonicalName()); |
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| 49 | this.scoreThreshold = threshold; |
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| 50 | |
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| 51 | matrix = new MatrixEntry[length1+2][length2+1]; |
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| 52 | |
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[1559] | 53 | for (int i = 0; i <= length1+1; i++) { |
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[1558] | 54 | for(int j = 0; j< length2; j++) { |
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| 55 | matrix[i][j] = new MatrixEntry(); |
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| 56 | } |
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| 57 | } |
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| 58 | |
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| 59 | |
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| 60 | buildMatrix(); |
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| 61 | } |
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| 62 | |
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| 63 | /** |
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| 64 | * Compute the similarity score of substitution The position of the first |
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| 65 | * character is 1. A position of 0 represents a gap. |
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| 66 | * |
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| 67 | * @param i |
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| 68 | * Position of the character in str1 |
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| 69 | * @param j |
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| 70 | * Position of the character in str2 |
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| 71 | * @return Cost of substitution of the character in str1 by the one in str2 |
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| 72 | */ |
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[1559] | 73 | private float similarity(int i, int j) { |
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[1558] | 74 | return submat.getDistance(input1[i - 1], input2[j - 1]); |
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| 75 | } |
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| 76 | |
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| 77 | /** |
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[1559] | 78 | * Build the score matrix using dynamic programming. |
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[1558] | 79 | */ |
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| 80 | private void buildMatrix() { |
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| 81 | if (submat.getGapPenalty() >= 0) { |
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| 82 | throw new Error("Indel score must be negative"); |
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| 83 | } |
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| 84 | |
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[1559] | 85 | // it's a gap |
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[1558] | 86 | matrix[0][0].setScore(0); |
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| 87 | matrix[0][0].setPrevious(null); // starting point |
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| 88 | |
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| 89 | // the first column |
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| 90 | for (int j = 1; j < length2; j++) { |
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| 91 | matrix[0][j].setScore(0); |
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| 92 | matrix[0][j].setPrevious(matrix[0][j-1]); |
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| 93 | |
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| 94 | } |
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| 95 | |
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| 96 | |
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| 97 | |
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[1559] | 98 | for (int i = 1; i <= length1 + 1; i++) { |
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[1558] | 99 | |
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| 100 | // Formula for first row: |
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| 101 | // F(i,0) = max { F(i-1,0), F(i-1,j)-T j=1,...,m |
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| 102 | |
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| 103 | float firstRowLeftScore = matrix[i-1][0].getScore(); |
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[1559] | 104 | //for sequences of length 1 |
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| 105 | float tempMax; |
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| 106 | int maxRowIndex; |
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| 107 | if(length2 == 1) { |
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| 108 | tempMax = matrix[i-1][0].getScore(); |
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| 109 | maxRowIndex = 0; |
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| 110 | } else { |
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| 111 | tempMax = matrix[i-1][1].getScore(); |
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| 112 | maxRowIndex = 1; |
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| 113 | //position of the maximal score of the previous row |
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| 114 | |
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| 115 | for(int j = 2; j < length2;j++) { |
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| 116 | if(matrix[i-1][j].getScore() > tempMax) { |
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| 117 | tempMax = matrix[i-1][j].getScore(); |
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| 118 | maxRowIndex = j; |
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| 119 | } |
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[1558] | 120 | } |
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[1559] | 121 | |
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[1558] | 122 | } |
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| 123 | |
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[1559] | 124 | |
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[1558] | 125 | tempMax -= scoreThreshold; |
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| 126 | matrix[i][0].setScore(Math.max(firstRowLeftScore, tempMax)); |
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[1559] | 127 | if(tempMax ==matrix[i][0].getScore()){ |
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| 128 | matrix[i][0].setPrevious(matrix[i-1][maxRowIndex]); |
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| 129 | } |
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[1558] | 130 | |
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[1559] | 131 | if(firstRowLeftScore == matrix[i][0].getScore()) { |
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| 132 | matrix[i][0].setPrevious(matrix[i-1][0]); |
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| 133 | } |
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[1558] | 134 | |
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[1559] | 135 | //The last additional score is not related to a character in the input sequence, it's the total score. Therefore we don't need to save something for it |
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| 136 | if(i<length1+1) |
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| 137 | { |
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| 138 | matrix[i][0].setXvalue(input1[i-1]); |
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| 139 | matrix[i][0].setYvalue(-2); |
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| 140 | |
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| 141 | } |
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| 142 | else { |
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| 143 | //End after we calculated final score |
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| 144 | return; |
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| 145 | } |
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| 146 | |
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| 147 | |
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[1558] | 148 | for (int j = 1; j < length2; j++) { |
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| 149 | float diagScore = matrix[i - 1][j - 1].getScore() + similarity(i, j); |
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[1559] | 150 | float upScore = matrix[i][j - 1].getScore() + submat.getGapPenalty(); |
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| 151 | float leftScore = matrix[i - 1][j].getScore() + submat.getGapPenalty(); |
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[1558] | 152 | |
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| 153 | matrix[i][j].setScore(Math.max(diagScore,Math.max(upScore, Math.max(leftScore,matrix[i][0].getScore())))); |
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| 154 | |
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| 155 | // find the directions that give the maximum scores. |
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| 156 | // Multiple directions are ignored TODO |
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[1559] | 157 | //True if we had a match |
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[1558] | 158 | if (diagScore == matrix[i][j].getScore()) { |
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| 159 | matrix[i][j].setPrevious(matrix[i-1][j-1]); |
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[1559] | 160 | matrix[i][j].setXvalue(input1[i-1]); |
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| 161 | matrix[i][j].setYvalue(input2[j-1]); |
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[1558] | 162 | } |
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[1559] | 163 | //true if we took an event from sequence x and not from y |
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[1558] | 164 | if (leftScore == matrix[i][j].getScore()) { |
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[1559] | 165 | matrix[i][j].setXvalue(input1[i-1]); |
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| 166 | matrix[i][j].setYvalue(-1); |
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[1558] | 167 | matrix[i][j].setPrevious(matrix[i-1][j]); |
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| 168 | } |
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[1559] | 169 | //true if we took an event from sequence y and not from x |
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[1558] | 170 | if (upScore == matrix[i][j].getScore()) { |
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[1559] | 171 | matrix[i][j].setXvalue(-1); |
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| 172 | matrix[i][j].setYvalue(input2[j-1]); |
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[1558] | 173 | matrix[i][j].setPrevious(matrix[i][j-1]); |
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| 174 | } |
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[1559] | 175 | //true if we ended a matching region |
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[1558] | 176 | if (matrix[i][0].getScore() == matrix[i][j].getScore()) { |
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[1559] | 177 | matrix[i][j].setPrevious(matrix[i][0]); |
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| 178 | matrix[i][j].setXvalue(input1[i-1]); |
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| 179 | matrix[i][j].setYvalue(-2); |
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[1558] | 180 | } |
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| 181 | } |
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[1559] | 182 | |
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| 183 | //Set the complete score cell |
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| 184 | |
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[1558] | 185 | } |
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| 186 | } |
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| 187 | |
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| 188 | /** |
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| 189 | * Get the maximum value in the score matrix. |
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| 190 | */ |
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| 191 | public double getMaxScore() { |
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| 192 | double maxScore = 0; |
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| 193 | |
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| 194 | // skip the first row and column |
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| 195 | for (int i = 1; i <= length1; i++) { |
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| 196 | for (int j = 1; j < length2; j++) { |
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| 197 | if (matrix[i][j].getScore() > maxScore) { |
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| 198 | maxScore = matrix[i][j].getScore(); |
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| 199 | } |
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| 200 | } |
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| 201 | } |
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| 202 | |
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| 203 | return maxScore; |
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| 204 | } |
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| 205 | |
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| 206 | /** |
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| 207 | * Get the alignment score between the two input strings. |
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| 208 | */ |
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[1559] | 209 | public float getAlignmentScore() { |
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| 210 | return matrix[length1+1][0].getScore(); |
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[1558] | 211 | } |
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| 212 | |
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| 213 | |
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| 214 | |
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| 215 | |
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| 216 | /** |
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| 217 | * given the bottom right corner point trace back the top left conrner. at |
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| 218 | * entry: i, j hold bottom right (end of Aligment coords) at return: hold |
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| 219 | * top left (start of Alignment coords) |
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| 220 | */ |
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| 221 | private int[] traceback(int i, int j) { |
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[1559] | 222 | |
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| 223 | |
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[1558] | 224 | return null; |
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| 225 | } |
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[1559] | 226 | |
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| 227 | public void traceback() { |
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| 228 | MatrixEntry tmp = matrix[length1+1][0]; |
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| 229 | String aligned1 = ""; |
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| 230 | String aligned2 = ""; |
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| 231 | int count = 0; |
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| 232 | do |
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| 233 | { |
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| 234 | String append1=""; |
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| 235 | String append2=""; |
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| 236 | |
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| 237 | if(tmp.getXvalue() == -1) { |
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| 238 | append1 = " ___"; |
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| 239 | } |
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| 240 | else if(tmp.getXvalue() == -2) { |
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| 241 | append1 = " ..."; |
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| 242 | } |
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| 243 | else { |
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| 244 | append1 = String.format("%5d", tmp.getXvalue()); |
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| 245 | } |
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[1558] | 246 | |
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[1559] | 247 | if(tmp.getYvalue() == -1) { |
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| 248 | append2 = " ___"; |
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| 249 | } |
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| 250 | else if(tmp.getYvalue() == -2) { |
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| 251 | append2 = " ..."; |
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| 252 | } |
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| 253 | else { |
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| 254 | append2 = String.format("%5d", tmp.getYvalue()); |
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| 255 | } |
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| 256 | if(count != 0) |
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| 257 | { |
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| 258 | aligned1 = append1 + aligned1; |
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| 259 | aligned2 = append2 + aligned2; |
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| 260 | } |
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| 261 | |
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| 262 | tmp = tmp.getPrevious(); |
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| 263 | count++; |
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| 264 | |
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| 265 | } while(tmp != null); |
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| 266 | System.out.println(aligned1); |
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| 267 | System.out.println(aligned2); |
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| 268 | } |
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[1558] | 269 | |
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[1559] | 270 | |
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| 271 | |
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[1558] | 272 | /** |
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| 273 | * print the dynmaic programming matrix |
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| 274 | */ |
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| 275 | public void printDPMatrix() { |
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| 276 | System.out.print(" "); |
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| 277 | for (int i = 1; i <= length1; i++) |
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| 278 | System.out.format("%5d", input1[i - 1]); |
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| 279 | System.out.println(); |
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| 280 | for (int j = 0; j < length2; j++) { |
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| 281 | if (j > 0) |
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| 282 | System.out.format("%5d ",input2[j - 1]); |
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| 283 | else{ |
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| 284 | System.out.print(" "); |
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| 285 | } |
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[1559] | 286 | for (int i = 0; i <= length1 + 1; i++) { |
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| 287 | if((i<length1+1) || (i==length1+1 && j==0)) { |
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| 288 | System.out.format("%4.1f ",matrix[i][j].getScore()); |
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| 289 | } |
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| 290 | |
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| 291 | } |
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[1558] | 292 | System.out.println(); |
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| 293 | } |
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| 294 | } |
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| 295 | |
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| 296 | /** |
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| 297 | * Return a set of Matches identified in Dynamic programming matrix. A match |
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| 298 | * is a pair of subsequences whose score is higher than the preset |
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| 299 | * scoreThreshold |
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| 300 | **/ |
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| 301 | public List<Match> getMatches() { |
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| 302 | ArrayList<Match> matchList = new ArrayList(); |
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| 303 | int fA = 0, fB = 0; |
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| 304 | // skip the first row and column, find the next maxScore after |
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| 305 | // prevmaxScore |
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| 306 | for (int i = 1; i <= length1; i++) { |
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| 307 | for (int j = 1; j <= length2; j++) { |
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| 308 | if (matrix[i][j].getScore() > scoreThreshold |
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| 309 | && matrix[i][j].getScore() > matrix[i - 1][j - 1].getScore() |
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| 310 | && matrix[i][j].getScore() > matrix[i - 1][j].getScore() |
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| 311 | && matrix[i][j].getScore() > matrix[i][j - 1].getScore()) { |
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| 312 | if (i == length1 || j == length2 |
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| 313 | || matrix[i][j].getScore() > matrix[i + 1][j + 1].getScore()) { |
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| 314 | // should be lesser than prev maxScore |
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| 315 | fA = i; |
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| 316 | fB = j; |
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| 317 | int[] f = traceback(fA, fB); // sets the x, y to |
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| 318 | // startAlignment |
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| 319 | // coordinates |
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| 320 | System.out.println(f[0] + " " + i + " " + f[1] + " " |
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| 321 | + j + " " + matrix[i][j].getScore()); |
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| 322 | // TODO Add matches to matchList |
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| 323 | } |
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| 324 | } |
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| 325 | } |
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| 326 | } |
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| 327 | return matchList; |
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| 328 | } |
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| 329 | |
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| 330 | } |
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